Sparse canonical correlation analysis for identifying, connecting and completing gene-expression networks |
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| Authors: | Sandra Waaijenborg and Aeilko H Zwinderman |
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| Institution: | (1) Clinical Epidemiology, Biostatistics & Bioinformatics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, the Netherlands |
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| Abstract: | Background We generalized penalized canonical correlation analysis for analyzing microarray gene-expression measurements for checking
completeness of known metabolic pathways and identifying candidate genes for incorporation in the pathway. We used Wold's
method for calculation of the canonical variates, and we applied ridge penalization to the regression of pathway genes on
canonical variates of the non-pathway genes, and the elastic net to the regression of non-pathway genes on the canonical variates
of the pathway genes. |
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