|
|||||
|
|
Microbial hydroxylation of progesterone with Acremonium strictum |
|
| Authors: | Faramarzi Mohammad Ali Tabatabaei Yazdi Mojtaba Amini Mohsen Zarrini Gholamreza Shafiee Abbas |
| Institution: | Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, 14174, Tehran, Iran. |
| Abstract: | Microbial hydroxylation of progesterone occurred in the culture of Acremonium strictum PTCC 5282 to produce two hydroxylated pregnene-like steroids. The metabolites were purified and characterized using spectroscopic methods and identified as 15alpha-hydroxyprogesterone and 15alpha-hydroxydeoxycorticosterone. |
| Keywords: | Biotransformation Microbial hydroxylation Progesterone Steroid Acremonium strictum |
| 本文献已被 PubMed 等数据库收录！ | |