首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Thyroid status,but not insulin status,affects expression of avian uncoupling protein mRNA in chicken
Authors:Collin Anne  Taouis Mohammed  Buyse Johan  Ifuta Ndey B  Darras Veerle M  Van As Pieter  Malheiros Ramon D  Moraes Vera M B  Decuypere Eddy
Institution:Station de Recherches Avicoles, Institut National de la Recherche Agronomique, F-37380 Nouzilly, France. collin@tours.inra.fr
Abstract:The aim of this study was to investigate the hormonal regulation of the avian homolog of mammalian uncoupling protein (avUCP) by studying the impact of thyroid hormones and insulin on avUCP mRNA expression in chickens (Gallus gallus). For 3 wk, chicks received either a standard diet (control group), or a standard diet supplemented with triiodothyronine (T(3); T3 group) or with the thyroid gland inhibitor methimazole (MMI group). A fourth group received injections of the deiodinase inhibitor iopanoic acid (IOP group). During the 4th wk of age, all animals received two daily injections of either human insulin or saline solution. The results indicate a twofold overexpression of avUCP mRNA in gastrocnemius muscle of T3 birds and a clear downregulation (-74%) in MMI chickens compared with control chickens. Insulin injections had no significant effect on avUCP mRNA expression in chickens. This study describes for the first time induction of avUCP mRNA expression by the thermogenic hormone T(3) in chickens and supports a possible involvement of avUCP in avian thermogenesis.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号