New Nitrogen‐Containing Sesquiterpenoids from the Taiwanese Soft Coral Cespitularia taeniata May |
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| Authors: | Yuan‐Bin Cheng Ching‐Yeu Chen Yao‐Haur Kuo Ya‐Ching Shen |
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| Affiliation: | 1. School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan, R.O.C. (phone: +886‐2‐23123456 ext. 2226;2. fax: +886‐2‐022391‐9098);3. Department of Marine Biotechnology and Resources, National Sun Yat‐Sen University, Kaohsiung 804, Taiwan, R.O.C.;4. Center for General Education, Tzu‐Hui Institute of Technology, Pingtung 926, Taiwan, R.O.C.;5. National Research Institute of Chinese Medicine, Taipei 112, Taiwan, R.O.C. |
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| Abstract: | Chemical investigation of the EtOH extract of the soft coral Cespitularia taeniata May collected in Taiwan has resulted in the isolation of two new sesquiterpene lactams, taenialactams A and B ( 1 and 2 , resp.), and a new sesquiterpene lactone, taenialactone A ( 3 ), together with 8β‐methoxyatractylenolide ( 4 ) and atractylenolactam ( 5 ). The structures of these compounds were determined on the basis of spectroscopic analyses. The in vitro cytotoxic activities of the isolated metabolites were tested against KB, Daoy, and WiDr cell lines. A biogenetic pathway for these novel compounds was proposed. |
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| Keywords: | Cespitularia taeniata Sesquiterpenes Lactams Taenialactams A and B Lactones Soft corals Taenialactone A Cytotoxic activity |
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