Two New Triterpenoid Saponins Cytotoxic to Human Glioblastoma U251MG Cells from Ardisia pusilla |
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| Authors: | Hai‐Feng Tang Jun Yun Hou‐Wen Lin Xiao‐Li Chen Xiao‐Juan Wang Guang Cheng |
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| Affiliation: | 1. Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 15 Changle West Road, Xi'an 710032, P.?R. China (phone/fax: +86‐29‐84775471);2. Department of Vascular Surgery, Xijing Hospital, Fourth Military Medical University, 15 Changle West Road, Xi'an 710032, P.?R. China;3. First co‐author.;4. Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, P.?R. China;5. Department of Pharmacy, School of Stomatology, Fourth Military Medical University, 1 Kangfu Road, Xi'an 710032, P.?R. China;6. Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, 15 Changle West Road, Xi'an 710032, P.?R. China |
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| Abstract: | Two new triterpenoid saponins, ardipusillosides IV and V ( 1 and 2 , resp.), together with one known saponin, ardisiacrispin B ( 3 ), were isolated from the whole plants of Ardisia pusilla A. DC. Their structures were deduced by extensive spectral analysis and chemical evidences. Compound 1 contains a glycosylated glycerol residue which is a very rare structural feature among triterpenoid glycosides and has been so far found only in the genus Ardisia. All the saponins exhibited significant cytotoxicity against human glioblastoma U251MG cells, but did not affect the growth of primary cultured human astrocytes. |
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| Keywords: | Triterpenoids Ardipusillosides IV and V Ardisia pusilla Saponins Cytotoxic activity |
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