Chemiluminescence determination of chlorpheniramine using tris(1,10‐phenanthroline)–ruthenium(II) peroxydisulphate system and sequential injection analysis |
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Authors: | Fakhr Eldin O Suliman Mohammed M Al‐Hinai Salma M Z Al‐Kindy Salama B Salama |
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Institution: | Department of Chemistry, College of Science, Sultan Qaboos University, Box 36, Al‐Khod 123, Sultanate of Oman |
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Abstract: | A sequential injection (SI) method was developed for the determination of chlorpheniramine (CPA), based on the reaction of this drug with tris(1,10‐phenanthroline)–ruthenium(II) Ru(phen)32+] and peroxydisulphate (S2O82–) in the presence of light. The instrumental set‐up utilized a syringe pump and a multiposition valve to aspirate the reagents Ru(phen)32+ and S2O82–] and a peristaltic pump to propel the sample. The experimental conditions affecting the chemiluminescence reaction were systematically optimized, using the univariate approach. Under the optimum conditions linear calibration curves of 0.1–10 µg/ml were obtained. The detection limit was 0.04 µg/ml and the relative standard deviation (RSD) was always < 5%. The procedure was applied to the analysis of CPA in pharmaceutical products and was found to be free from interferences from concomitants usually present in these preparations. Copyright © 2008 John Wiley & Sons, Ltd. |
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Keywords: | chemiluminescence tris(1 10‐phenanthroline)– ruthenium(II) peroxydisulphate chlorpheniramine |
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