Linkage disequilibrium patterns and genetic structure of Amerindian and non‐Amerindian Brazilian populations revealed by long‐range X‐STR markers |
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| Authors: | Fabio PN Leite Sidney EB Santos Elzemar MR Rodríguez Sidia M Callegari‐Jacques Dario A Demarchi Luiza T Tsuneto M Luiza Petzl‐Erler Francisco M Salzano Mara H Hutz |
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| Institution: | 1. Laboratório de Perícias, Instituto Geral de Perícias, Porto Alegre, RS, Brazil;2. Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil;3. Laboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém, PA, Brazil;4. Departamento de Estatística, Universidade Federal do Rio Grande do Sul, Campus do Vale, Porto Alegre, RS, Brazil;5. Universidad Nacional de Córdoba, Museo de Antropologia, Córdoba, Argentina;6. Departamento de Genética, Universidade Federal do Paraná, Curitiba, PR, Brazil |
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| Abstract: | The extent of X‐chromosome linkage disequilibrium (LD) was studied in a southern Brazilian population, and in a pool of samples from Amerindian populations. For this purpose, 11 microsatellites, located mostly in a Xq region comprising ～86 Mb was investigated. The lower Amerindian gene diversity associated with significant differences between the populations studied indicated population structure as the main cause for the higher LD values in the Amerindian pool. On the other hand, the LD levels of the non‐Amerindian Brazilian sample, although less extensive than that of the Amerindians, were probably determined by admixture events. Our results indicated that different demographic histories have significant effects on LD levels of human populations, and provide a first approach to the X‐chromosome ancestry of Amerindian and non‐Amerindian Brazilian populations, being valuable for future studies involving mapping and population genetic studies. Am J Phys Anthropol 2009. © 2009 Wiley‐Liss, Inc. |
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| Keywords: | X‐chromosome microsatellites Brazil Native Americans population diversity linkage disequilibrium |
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