Biomimetic potential of some methacrylate‐based copolymers: A comparative study |
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Authors: | Teodora Zecheru Robert Filmon Edina Rusen Bogdan Mărculescu Amar Zerroukhi Corneliu Cincu Daniel Chappard |
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Affiliation: | 1. INSERM, U922, LHEA, Faculty of Medicine, University of Angers, 1 rue Haute de Reculée, Angers Cedex 49045, France;2. Department Science and Engineering of Polymers, University POLITEHNICA of Bucharest, 149 Calea Victoriei, Bucharest 010072, Romania;3. Faculty of Sciences and Techniques, University Jean Monnet of Saint Etienne, 23 rue Dr. Paul Michelon, Saint Etienne Cedex 2 42023, France |
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Abstract: | Preparation of new biocompatible materials for bone recovery has consistently gained interest in the last few decades. Special attention was given to polymers that contain negatively charged groups, such as phosphate, carboxyl, and sulfonic groups toward calcification. This present paper work demonstrates that other functional groups present also potential application in bone pathology. New copolymers of 2‐hydroxyethyl methacrylate with diallyldimethylammonium chloride (DADMAC), glycidyl methacrylate (GlyMA), methacrylic acid (MAA), 2‐methacryloyloxymethyl acetoacetate (MOEAA), 2‐methacryloyloxyethyltriethylammonium chloride (MOETAC), and tetrahydrofurfuryl methacrylate (THFMA) were obtained. The copolymers were characterized by FTIR, swelling potential, and they were submitted to in vitro tests for calcification and cytotoxicity evaluation. GlyMA and MOETAC‐containing copolymers show promising results for further in vivo mineralization tests, as a potential alternative to the classical bone grafts, in bone tissue engineering. © 2009 Wiley Periodicals, Inc. Biopolymers 91: 966–973, 2009. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com |
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Keywords: | biopolymer biocompatibility in vitro calcification HEMA tissue engineering |
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