Biocatalytic Production of Acyclic Bis[bibenzyls] from Dihydroresveratrol by Crude Momordica charantia Peroxidase |
| |
| Authors: | Chun‐Feng Xie Hui‐Qing Yuan Jian‐Bo Qu Jie Xing Bei‐Bei Lü Xiao‐Ning Wang Mei Ji Hong‐Xiang Lou |
| |
| Institution: | 1. School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, P.?R. China (phone: +86‐531‐8382012;2. fax: +86‐531‐8382019);3. School of Medicine, Shandong University, 44 West Wenhua Road, Jinan 250012, P.?R. China |
| |
| Abstract: | Biotransformation of dihydroresveratrol by crude Momordica charantia peroxidase provided six new acyclic bisbibenzyls] 1 – 6 . Their structures were established on the basis of NMR and MS analyses as C? C, C? O? C, and C? CH2? C dimers of dihydroresveratrol. Compounds 1 – 6 were tested for antiproliferative activity against human prostate cancer PC3 cell line in vitro, and 2 and 6 were found to be more potent than the parent compound. |
| |
| Keywords: | Biocatalysis Bis[bibenzyls] Dihydroresveratrol Momordica charantia peroxidase Enzymatic catalysis Antiproliferative activity |
|
|
