Colomitides A and B: Novel Ketals with an Unusual 2,7‐Dioxabicyclo[3.2.1]octane Ring System from the Aquatic Fungus YMF 1.01029 |
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| Authors: | Jin‐Yan Dong Li‐Mei Wang Hong‐Chuang Song Kai‐Ze Shen Yong‐Ping Zhou Le Wang Ke‐Qin Zhang |
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| Institution: | 1. Laboratory for Conservation and Utilization of Bio‐Resources, and Key Laboratory for Microbial Resources of the Chinese Ministry of Education, Yunnan University, Kunming 650091, P.?R. China, (phone: +86‐871‐5034878;2. fax: +86‐871‐5034838);3. Provincial Key Laboratory of Rural Energy Engineering, Yunnan Normal University, Kunming 650092, P.?R. China |
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| Abstract: | Two novel diastereoisomeric bicyclic ketals, colomitides A and B ( 1 and 2 , resp.), together with the known (4RS)‐3,4‐dihydro‐4,8‐dihydroxynaphthalen‐1(2H)‐one ( 3 ) and preussomerin E ( 4 ), were isolated from liquid cultures of an unidentified freshwater fungus YMF 1.01029. Colomitides possess an unusual 2,7‐dioxabicyclo3.2.1]octane skeleton. The chemical structures and relative configurations of compounds 1 and 2 were elucidated by spectroscopic means, including 2D‐NMR (HMBC, HMQC, TOCSY, ROESY, and 1H,1H‐COSY). Compounds 1, 2 , and 4 showed noticeable antifungal and antibacterial activities. |
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| Keywords: | Colomitides A and B Ketals Fungi Antifungal activity Antibacterial activity |
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