Adsorption of the PtII Anticancer Drug Carboplatin by Mesoporous Silica |
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| Authors: | Anthony J. Di Pasqua Silvia Wallner Deborah J. Kerwood James C. Dabrowiak |
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| Affiliation: | 1. Department of Chemistry, Syracuse University, 111 College Place, CST, Rm 1‐014, Syracuse, New York 13244‐4100, USA (phone: 315‐443‐4601;2. fax: 315‐443‐4070) |
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| Abstract: | MCM‐41, a mesoporous silica nanomaterial with a high surface area for adsorption of small molecules, is a potential new type of delivery vehicle for therapeutic and diagnostic agents. In this report, we show that MCM‐41 adsorbs the front‐line anticancer drug carboplatin, [Pt(CBDCA‐O,O′)(NH3)2] (CBDCA=cyclobutane‐1,1‐dicarboxylate; 1 ), which is used to treat ovarian, lung, and other types of cancer. UV/Visible difference absorption spectroscopy shows that MCM‐41 adsorbs 1.8±0.2% of its own weight of carboplatin after a 24 h exposure to 26.9 mM drug in H2O. The pseudo‐first‐order rate constant for adsorption of carboplatin by MCM‐41, measured using [1H,15N] heteronuclear single quantum coherence (HSQC) NMR, and 15N‐labeled carboplatin is k1=2.92±2.17×10?6 s?1 at ca. 25°. |
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| Keywords: | Carboplatin MCM‐41 Nanomaterials Drug delivery Platinum complexes Mesoporous silica |
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