Chemical Constituents from the Whole Plant of Gaultheria itoana Hayata |
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| Authors: | Chung‐Yi Chen Rong‐Jyh Lin Jin‐Cherng Huang Yi‐Hung Wu Ming‐Jen Cheng His‐Chou Hung Wen‐Li Lo |
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| Institution: | 1. Department of Medical Technology, School of Medical and Health Science, Fooyin University, Kaohsiung 831, Taiwan (phone: +886‐7‐7811151 ext. 5414);2. Department of Parasitology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan;3. First co‐author.;4. Department of Forestry and Natural Resources College of Agriculture, National Chiayi University, Chiayi 600, Taiwan;5. Alishan Station Chiayi Forest District Office, Forestry Bureau, Chiayi 600, Taiwan;6. Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan 300, Taiwan;7. Tapei Station Luodong Forest District Office, Forestry Bureau, Luodong 265, Taiwan |
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| Abstract: | Two new diterpenoids, 14,18‐dihydroxyabieta‐8,11,13‐trien‐7‐one ( 1 ) and 13‐acetyl‐14,18‐dihydroxy‐podocarpa‐8,11,13‐triene ( 2 ), together with eight known compounds, i.e., gaultheric acid ( 3 ), vanillic acid ( 4 ), 4‐hydroxybenzoic acid ( 5 ), cinnamic acid ( 6 ), stearic acid ( 7 ), palmitic acid ( 8 ), β‐sitosterol ( 9 ), and stigmasterol ( 10 ), were isolated from the MeOH extract of the whole plant of Gaultheria itoana Hayata (Ericaceae). The structures of the new constituents were elucidated by spectroscopic methods (UV, IR, and 1D‐ and 2D‐NMR) and by mass spectrometry (HR‐ESI‐MS). Among them, 1 and 2 were demonstrated to exhibit significant cytotoxic activity against the LNCaP cell line. |
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| Keywords: | Gaultheria itoana Diterpenoids Abietanes Podocarpanes Cytotoxic activity |
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