Chemiluminescence method for the determination of piroxicam by the enhancement of the tris‐(4,7‐diphenyl‐1,10‐phenanthrolinedisulphonic acid) ruthenium(II) (RuBPS)–cerium(IV) system and its application |
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| Authors: | Fengshan Yu Yangbin Zhang Fang Chen Lanhua Chen |
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| Institution: | 1. Department of Chemistry, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, Wuhan 430074, People's Republic of China;2. Department of Chemistry, Liji High School of Suining, Xuzhou 221221, People's Republic of China;3. Department of Chemistry, Huaibei Coal Industry Teachers' College, Huaibei 235000, People's Republic of China |
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| Abstract: | A simple, rapid chemiluminescence (CL) method was described for the determination of piroxicam, a commonly used analgesic agent drug. A strong CL signal was detected when cerium(IV) sulphate was injected into tris‐(4,7‐diphenyl‐1,10‐phenanthrolinedisulphonic acid) ruthenium(II) (RuBPS)–piroxicam solution. The CL signal was proportional to the concentration of piroxicam in the range 2.8 × 10–8–1.2 × 10–5 mol/L. The detection limit was 2 × 10–8 mol/L and the relative standard deviation (RSD) was 3.7% (c = 7.0 × 10–7 mol/L piroxicam; n = 11). The proposed method was applied to the determination of piroxicam in pharmaceutical preparations in capsules, spiked serum and urine samples with satisfactory results. Copyright © 2008 John Wiley & Sons, Ltd. |
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| Keywords: | chemiluminescence tris‐(4 7‐diphenyl‐1 10‐phenanthrolinedisulphonic acid) ruthenium(II) cerium(IV) piroxicam |
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