Crassocolides G–M,Cembranoids from the Formosan Soft Coral Sarcophyton crassocaule |
| |
| Authors: | Ho‐Cheng Huang Chih‐Hua Chao Yao‐Haur Kuo Jyh‐Horng Sheu |
| |
| Institution: | 1. Department of Chemical and Materials Engineering, Cheng Shiu University, Kaohsiung 833, Taiwan;2. Department of Marine Biotechnology and Resources, National Sun Yat‐Sen University, Kaohsiung 804, Taiwan (phone: +886?–?7‐5255030;3. fax: +886?–?7‐5255020);4. National Research Institute of Chinese Medicine, Taipei 112, Taiwan |
| |
| Abstract: | Seven new polyoxygenated cembranoids possessing an α‐methylene‐γ‐lactone group, crassocolides G–M ( 1 – 7 , resp.), have been isolated from the AcOEt extract of the Formosan soft coral Sarcophyton crassocaule. The structures of compounds 1 – 7 were established by detailed spectroscopic analyses, including 2D‐NMR spectroscopy (1H,1H‐COSY, HMQC, HMBC, and NOESY), while the absolute configuration of 1 was determined using a modified reaction of Mosher's method. The cytotoxicity of compounds 1 – 7 against a limited panel of cancer cell lines was also determined. |
| |
| Keywords: | Sarcophyton crassocaule Soft corals Crassocolides G – M Cembranoids Cytotoxic activity |
|
|
