Sinuladiterpenes A–F,New Cembrane Diterpenes from Sinularia flexibilis |
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| Authors: | Kuang‐Liang Lo Ashraf Taha Khalil Yao‐Haur Kuo Ya‐Ching Shen |
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| Institution: | 1. Department of Marine Biotechnology and Resources, National Sun Yat‐Sen University, Kaohsiung 804, Taiwan;2. School of Pharmacy, College of Medicine, National Taiwan University, Jen‐Ai Rd. Sec. 1, Taipei 100, Taiwan (phone: +886‐2‐2312‐3456 ext. 62226;3. fax: +886‐2‐02‐2391‐9098);4. National Research Institute of Chinese Medicine, Taipei, Taiwan |
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| Abstract: | Chromatographic investigation of the octocoral Sinularia flexibilis afforded six new cembrane diterpenes, sinuladiterpenes A–F ( 1 – 6 , resp.), in addition to four known cembranolides, 11‐episinulariolide acetate, 11 ‐ dehydrosinulariolide, 11‐episinulariolide, and sinulariolide. Their structures were elucidated by spectroscopic analysis, especially 2D‐NMR and HR‐ESI‐MS. Compound 2 exhibited significant in vitro cytotoxic activity against human colon adenocarcinoma (WiDr) cell line. |
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| Keywords: | Sinularia flexibilis Soft corals Cembrane diterpenes Sinuladiterpenes A – F Cytotoxic activity Diterpenes |
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