New thiazane and thiazolidine PNA monomers: synthesis, incorporation into PNAs and hybridization studies |
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| Authors: | Bregant Sarah Burlina Fabienne Chassaing Gérard |
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| Affiliation: | Laboratoire de Chimie Organique Biologique, Université P. et M. Curie, CNRS-UMR 7613, 4 place Jussieu, 75252 Paris Cedex 05, France. |
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| Abstract: | New constrained PNA monomers containing a substituted thiazolidine or a thiazane ring were synthesized and incorporated in the center of a 9-mer homothymine PNA. The PNA/DNA hybrids stability was studied by UV-melting experiments which showed that the presence of the modified unit destabilizes the PNA/DNA triplexes. |
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