The severity of coronary artery disease and reversible ischemia revealed by N-terminal pro-brain natriuretic peptide in patients with unstable angina and preserved left ventricular function |
| |
| Affiliation: | 1. Institute of Cardiovascular Disease Research, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu 221002, China;2. Department of Cardiology, The Affiliated Hospital of Xuzhou Medical College, 99 West Huaihai Road, Xuzhou, Jiangsu 221002, China;1. Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha 410081, China;2. Department of Biotechnology and Environmental Science, Changsha University, Changsha 410003, China;1. Natural Drug Discovery Group, School of Pharmacy, Queen''s University, Belfast BT9 7BL, Northern Ireland, UK;2. School of Medicine, Shenzhen University, PR China;3. Division of Molecular Cardiology, Department of Internal Medicine, College of Medicine, Texas A&M University Health Science Center, Central Texas Veterans Health Care System, Temple, TX 76504, USA;1. Deane Prostate Health and Research Center, Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY;2. Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY;3. Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY;1. Department of Urology, Yale University School of Medicine, New Haven, CT, USA;2. Department of Urology, University of California San Francisco, San Francisco, CA, USA;3. Department of Pathology, University of California San Francisco, San Francisco, CA, USA;4. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA |
| |
| Abstract: | The association between the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and the severity of coronary artery disease (CAD) diagnosed by coronary angiography and other approaches has been investigated. The clinical application of NT-proBNP is restricted by the drawbacks of these techniques now available in screening out patients who need intensive or conservative treatment. Fractional flow reserve (FFR) is superior to coronary angiography and other functional indicators. Accordingly, we designed to investigate the association between NT-proBNP and myocardial ischemia from the perspective of anatomy and physiology in patients with unstable angina and preserved left ventricular function. Plasma samples were collected from 110 patients and NT-proBNP levels were measured by radioimmunoassay. The severity of coronary artery stenosis in patients was measured by coronary angiography and FFR. Stenosis ≥50% in the left main artery or stenosis of 70%, and fractional flow reserve (FFR) ≤0.80 in one or more coronary branches with diameter ≥2 mm were defined as “positive”, which require revascularization. NT-proBNP levels increased progressively between patients with negative and positive angiographic results (p < 0.05), and between FFR-negative and FFR-positive patients (p < 0.05). A significant correlation was observed between log NT-proBNP and log GS (GS = Gensini score, p < 0.001). NT-proBNP level serves as a predictor of positive results of angiographic stenosis and FFR, with the area under the receiver operating characteristic curve being 0.697 and 0.787, respectively. NT-proBNP levels are correlated with the severity of anatomic coronary obstruction and inducible myocardial ischemia, but NT-proBNP per se is insufficient to identify clinically significant angiographic and physiological stenoses. |
| |
| Keywords: | N-terminal pro-brain natriuretic peptide Coronary artery disease Coronary angiography Fractional flow reserve |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
