Individual plasma ghrelin changes in the same patients in hyperthyroid,hypothyroid and euthyroid state |
| |
| Affiliation: | 1. Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego St., 60-355 Poznan, Poland;2. Department of Computer Science and Statistics, Poznan University of Medical Sciences, 79 Dabrowskiego St., 60-529 Poznan, Poland;1. Institute for Community Medicine, University Medicine Greifswald, Germany;2. DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Germany;3. Department of Internal Medicine B – Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University Medicine Greifswald, Germany;4. DZD (German Center for Diabetes Research), Site Greifswald, Germany;5. Research Centre for Prevention and Health, the Capital Region, Glostrup, Denmark;1. Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia;2. Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia;3. Physiology Unit, Faculty of Medicine, AIMST University, 08100 Bedong, Kedah, Malaysia;4. Department of Pre-clinical Sciences, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, 43000 Kajang, Selangor, Malaysia;1. Institut de Neurociències and Unitat de Bioestadística, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain;2. Network Biomedical Research Center on Mental Health (CIBERSAM), Spain |
| |
| Abstract: | Ghrelin is a multifunctional peptide of widespread expression. Since it has been shown to influence energy homeostatis, its potential role in thyroid dysfunction may have clinical significance. In this study, plasma ghrelin changes have been analyzed in the same patients in three different thyroid states for the first time. The study group consisted of 16 patients who had been diagnosed with hyperthyroidism, were treated with radioiodine, developed hypothyroidism after treatment, and finally became euthyroid on l-thyroxine substitution. In the initial state of hyperthyroidism plasma ghrelin levels correlated negatively with fT3 and fT4. In hypothyroidism ghrelin concentration increased significantly (p < 0.05). Although the mean value of plasma ghrelin tended to decrease in the euthyroid state, the individual difference between hypothyroidism and euthyroidism was not significant. Plasma ghrelin in euthyroidism was still significantly higher than in hyperthyroidism (p < 0.05), and correlated positively with ghrelin levels in hyperthyroidism and hypothyroidism. In our opinion, plasma ghrelin fluctuations may reflect metabolic changes in patients with thyroid dysfunction. Moreover, it cannot be excluded that in thyroid disorders ghrelin acts as a compensatory factor, helping to balance metabolic disturbances. |
| |
| Keywords: | Ghrelin Hyperthyroidism Hypothyroidism Thyroid dysfunction Metabolism |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
