Elevated plasma levels of soluble (pro)renin receptor in patients with obstructive sleep apnea syndrome: Association with polysomnographic parameters |
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| Institution: | 1. Division of Behavioral Sleep Medicine, Iwate Medical University School of Medicine, Morioka, Iwate 020-8505, Japan;2. Department of Endocrinology and Applied Medical Science, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan;1. Department of Physiology, Diabetic Research Center, Chonbuk National University Medical School, Jeonju, Republic of Korea;2. Department of Pharmacology, Taishan Medical University, Shandong, China;1. Institute of Ophthalmology and Visual Science, Rutgers University, Newark, NJ, United States;2. Department of Epidemiology and Health Promotion, NYU College of Dentistry, New York, NY, United States;3. Department of Pathology and Laboratory Medicine and NJMS Molecular Resource Facility, Rutgers University, Newark, NJ, United States;1. The Second Zone, Department of Brain, The People''s Hospital of Qingyuan, The Affiliated Qingyuan Hospital of Jinan University, B24 Xinchengyinquan Road, Qingcheng District, Qingyuan 511518, Guangdong Province, China;2. Department of Neurosurgery, The Central Hospital of Wenzhou City, 32 Dajian Lane, Wenzhou 325000, Zhejiang Province, China |
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| Abstract: | (Pro)renin receptor ((P)RR) is a specific receptor for both renin and its precursor prorenin. (P)RR was shown to be involved in pathophysiology of cardiovascular and renal diseases. Soluble (pro)renin receptor (s(P)RR), which is generated by furin from full length (P)RR, is present in blood. The aim of the present study is to clarify the association of plasma s(P)RR levels and the severity of OSAS. Plasma levels of s(P)RR were measured by ELISA in 58 male patients diagnosed as OSAS based on polysomnography, and 14 age-matched male control subjects. Blood samples were obtained at 6:00 a.m. just after overnight polysomnography. Plasma s(P)RR levels were significantly higher in patients with OSAS (9.0 ± 2.0 ng/mL, mean ± SD) than in control subjects (7.4 ± 1.5 ng/mL) (P = 0.0026). Plasma s(P)RR levels showed a significant negative correlation with % stage rapid eye movement (REM) sleep (r = ?0.377, p < 0.005), and significant positive correlations with % stage 1 (r = 0.374, p < 0.005), arousal index (r = 0.341, p < 0.01), apnea hypopnea index (AHI) (r = 0.352, p < 0.01) and desaturation index (r = 0.302, p < 0. 05). In 12 OSAS patients with AHI ≥20, plasma levels of s(P)RR were studied after 3-month treatment with nasal continuous positive airway pressure (nCPAP). Plasma s(P)RR levels were significantly decreased after the nCPAP treatment (p = 0.0016). The present study has shown for the first time elevated plasma s(P)RR levels in patients with OSAS. Plasma s(P)RR levels were associated with the severity of OSAS. Soluble (P)RR may serve as a plasma marker reflecting the severity of OSAS. |
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| Keywords: | Obstructive sleep apnea syndrome Soluble (pro)renin receptor Prorenin Renin Aldosterone Apnea hypopnea index |
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