Synthesis and antibacterial activity of 9-substituted minocycline derivatives |
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| Authors: | Sum Phaik-Eng Ross Adma T Petersen Peter J Testa Raymond T |
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| Institution: | Department of Chemical and Screening Sciences, Wyeth Research, Chemical Sciences Building 222/3147, 401 N. Middletown Road, Pearl River, NY 10965, USA. sump@wyeth.com |
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| Abstract: | A number of 9-acylamino and 9-sulfonylamino derivatives of minocycline have been synthesized for structure-activity relationship studies. These compounds showed activity against both tetracycline-susceptible and tetracycline-resistant strains. Many of the 9-sulfonylamino derivatives exhibited improved antibacterial activity against a number of tetracycline- and minocycline-resistant Gram-positive pathogens. |
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