Aging: the sins of the parents |
| |
Authors: | Haber James E |
| |
Institution: | Rosenstiel Center MS029, Brandeis University, Waltham, Massachusetts 02454-9110, USA. |
| |
Abstract: | Yeast cells have an asymmetric, stem-cell-like division. As the mother cell ages it becomes 100 times more genetically unstable, but it is only the daughter cells that exhibit loss of heterozygosity; the latter effect is not connected to SIR2-dependent aging, but seems to be accompanied by a loss of the DNA damage checkpoint. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|