| 血清抑癌多肽某些生物学特性的研究 |
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| 引用本文： | 白若力,刘莎,刘新华,章云津,陈明.血清抑癌多肽某些生物学特性的研究[J].中国生物化学与分子生物学报,1985,1(3):49-54. |
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| 作者姓名： | 白若力 刘莎 刘新华 章云津 陈明 |
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| 作者单位： | 北京医科大学生物化学教研室
(白若力，刘莎，刘新华，章云津)，北京医科大学生物化学教研室(陈明) |
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| 基金项目： | 中国科学院科学基金(生字376号) |
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| 摘 要： | 血清抑癌多肽(SCSP)在体外可以杀伤小鼠不同种类的腹水型癌细胞,如肝癌细胞、S180细胞、白血病细胞等。但它对小鼠的非癌细胞没有明显影响,对不同种类的人癌细胞株没有普遍的杀伤作用。 用反向间接血凝法检验结果表明,血清抑癌多肽可能由宿主脾细胞产生,而非来自癌细胞。 用超速离心法分离小鼠血清脂蛋白VLDL和HDL,并检测脂蛋白中SCSP含量与其对癌细胞杀伤作用的关系,相关性检验结果表明它们之间有相关关系。SCSP的含量高,则对癌细胞的杀伤作用强。
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| 关 键 词： | 血清抑癌多肽 台盼蓝排拒实验 反向间接血凝 艾氏腹水癌 超离心 血清脂蛋白 |
| 收稿时间： | 1985-06-20 |
A Study on Biological Characters of Serum Cancer-Suppressive Peptide |
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| Bai,RuoLi Liou Sha Liou,XinHua Zhan,YunJin Chen,Ming.A Study on Biological Characters of Serum Cancer-Suppressive Peptide[J].Chinese Journal of Biochemistry and Molecular Biology,1985,1(3):49-54. |
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| Authors: | Bai RuoLi Liou Sha Liou XinHua Zhan YunJin Chen Ming |
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| Institution: | Bai,RuoLi Liou Sha Liou,XinHua Zhan,YunJin Chen,Ming.Department of Biochiemistry,Beijing Medical university,Btijing. |
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| Abstract: | Serum Cancer-Suppressive Peptide (SCSP) had an ability to kill different ascitic cancer cells of mice in vitro, such as Hepatoma, Sarcoma 180, Leukemia, but had little effect on spleen cells. SCSP seemed unable to kill various human cancer cells.The results of passive hemagglutination method indicated that SCSP was probably produced by spleen cells of the host, but not from the cancer cells.The VLDL and HDL of mice sera were separated by ultracentrifugation. The results suggested that the content of SCSP in these two kinds of lipoproteins and their killing ability on cancer cells were correlated. Lipoprotein with higher titer of SCSP showed higher killing ability on cancer cells. |
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| Keywords: | Serum cancer-suppressive peptideTrypan blue exclusionReverse passive HemagglutinationEhrlich Ascites carcinomaUltracentrifugationSerum Lipoprotein |
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