Regulation of flagellar length in Chlamydomonas |
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Authors: | Wilson Nedra F Iyer Janaki Kannan Buchheim Julie A Meek William |
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Affiliation: | aDepartment of Anatomy and Cell Biology, Oklahoma State University Center for Health Sciences, 1111 W. 17th Street, Tulsa, OK 74107, United States |
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Abstract: | Chlamydomonas reinhardtii has two apically localized flagella that are maintained at an equal and appropriate length. Assembly and maintenance of flagella requires a microtubule-based transport system known as intraflagellar transport (IFT). During IFT, proteins destined for incorporation into or removal from a flagellum are carried along doublet microtubules via IFT particles. Regulation of IFT activity therefore is pivotal in determining the length of a flagellum. Reviewed is our current understanding of the role of IFT and signal transduction pathways in the regulation of flagellar length. |
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Keywords: | Chlamydomonas Flagellar length Cilia Intraflagellar transport Signal transduction |
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