Heterogeneity of mitochondrial creatine kinase |
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Authors: | Kanemitsu Fusae Kageoka Takeshi Kira Shohei |
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Affiliation: | Clinical Laboratories, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki 710-8602, Japan. fkl306@kchnet.or.jp |
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Abstract: | The heterogeneity of cardiac sarcomeric mitochondrial creatine kinase (creatine N-phosphotransferase, EC 2.7.3.2, sMi-CK), namely, brain ubiquitous Mi-CK (uMi-CK) and an atypical Mi-CK detected in the serum of a patient with ovarian cancer, was studied by isoelectric focusing. These Mi-CKs were found to be slightly different from each other with respect to their pIs under the examined conditions. The atypical Mi-CK was found to be an atypically oxidized form of uMi-CK. Results suggest that these heterogeneities of Mi-CK are caused by the genotypes, structures, biological functions and metabolism/dissimilation of Mi-CKs in the mitochondria and intravascular circulation. |
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