Effect of interleukin-1 on the augmentation of human immunodeficiency virus gene expression |
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| Authors: | N Kobayashi Y Hamamoto Y Koyanagi I S Chen N Yamamoto |
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| Affiliation: | Department of Virology and Parasitology, School of Medicine, Yamaguchi University, Japan. |
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| Abstract: | Among the cytokines tested here (IL-2, IL-3, IL-4, IL-5, IL-6, granulocyte colony stimulating factor (G-CSF), granulocyte/macrophage colony stimulating factor (GM-CSF), interferon-alpha (IFN-alpha), interferon-beta (IFN-beta) and interferon-gamma (IFN-gamma] only interleukin 1(IL-1) augmented HIV-long terminal repeat(LTR) directed chloramphenicol acetyl transferase(CAT) activity in protein kinase C(PKC)-independent manner. However, a stimulation by IL-1 was not as efficient as that due to tumor necrosis factor and the HIV production was not significant. IL-1 was not cytotoxic to MOLT-4/HIV cells. |
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