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Immunohistochemical analysis of connective tissue in patients with pelvic organ prolapse |
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| Authors: | Nese Yucel Ak?n Usta Kadir Guzin Mehmet Kanter Ergun Bilgic Nurver Ozbay Ozel Mustafa Ozgul |
| Institution: | 1. Clinics of Gynecology and Obstetric, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey 2. Department of Histology and Embryology, Faculty of Medicine, Istanbul Medeniyet University, 34730, Istanbul, Turkey 3. Department of Pathology, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey |
| Abstract: | The uterosacral ligaments are an important part of the pelvic support system. The objective of this study was to compare the expression of collagen type I and collagen type III in the uterosacral ligament biopsies from women with and without pelvic organ prolapse (POP). The uterosacral ligament biopsies were obtained from women with POP (n = 29) and non-POP subjects (n = 35). Immunohistochemistry for collagen type I and collagen type III was performed on formalin-fixed and paraffin-embedded sections. The two groups were matched for age, body mass index, parity and postmenopausal status. The expression of collagen type I (p < 0.001) and collagen type III (p < 0.0001) differed between women with POP and non-POP subjects. There was decreased expression of collagen type I and increased expression of collagen type III in uterosacral ligaments of women with POP compared with non-POP subjects. This difference indicates a possible relationship between POP and the immunohistochemical expression of collagen type I and collagen type III in uterosacral ligaments. |
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