Unexpected reductions of glycosyl spacer-armed phthalimides |
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| Authors: | Meng Xiang-Bao Li Hui Lou Qing-Hua Cai Meng-Shen Li Zhong-Jun |
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| Institution: | Department of Chemical Biology, School of Pharmaceutical Sciences, National Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China. |
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| Abstract: | An unusual reductive ring-opening reaction in the title compounds, of the phthalimide group with sodium hydride in anhydrous DMF is observed for the first time and the presumed mechanism is described in detail. An unexpected hydrogenation of the phthalimide group was also observed. |
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| Keywords: | Phthalimide Benzylation Hydrogenation Reduction |
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