SelSim: a program to simulate population genetic data with natural selection and recombination |
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Authors: | Spencer Chris C A Coop Graham |
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Institution: | Department of Statistics, 1 South Parks Road, Oxford OX1 3TG, UK. spencer@stats.ox.ac.uk |
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Abstract: | SUMMARY: SelSim is a program for Monte Carlo simulation of DNA polymorphism data for a recombining region within which a single bi-allelic site has experienced natural selection. SelSim allows simulation from either a fully stochastic model of, or deterministic approximations to, natural selection within a coalescent framework. A number of different mutation models are available for simulating surrounding neutral variation. The package enables a detailed exploration of the effects of different models and strengths of selection on patterns of diversity. This provides a tool for the statistical analysis of both empirical data and methods designed to detect natural selection. AVAILABILITY: http://www.stats.ox.ac.uk/mathgen/software.html. SUPPLEMENTARY INFORMATION: http://www.stats.ox.ac.uk/mathgen/software.html. |
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