Overexpression of the human <Emphasis Type="Italic">MNB/DYRK1A</Emphasis> gene induces formation of multinucleate cells through overduplication of the centrosome期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Overexpression of the human MNB/DYRK1A gene induces formation of multinucleate cells through overduplication of the centrosome

Authors:	Eishi?Funakoshi,Takamitsu?Hori,Tokuko?Haraguchi,Yasushi?Hiraoka,Jun?Kudoh,Nobuyoshi?Shimizu,Fumiaki?Ito author-information" > author-information__contact u-icon-before" > mailto:fito@pharm.setsunan.ac.jp" title=" fito@pharm.setsunan.ac.jp" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka 573-0101, Japan;(2) Communications Research Laboratory, Kansai Advanced Research Center, 588-2 Iwaoka, Iwaoka-cho, Nishi-ku Kobe, 651-2492, Japan;(3) Department of Biology, Graduate School of Science, Osaka University, 1-16 Machikaneyama, Osaka 560-0043, Japan;(4) Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan

Abstract:	Background Previously we cloned the human MNB/DYRK1A gene from the "Down syndrome critical region" on chromosome 21. This gene encodes a dual specificity protein kinase that catalyzes its autophosphorylation on serine/threonine and tyrosine residues. But, the functions of the MNB/DYRK1A gene in cellular processes are unknown.

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