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Overexpression of the human <Emphasis Type="Italic">MNB/DYRK1A</Emphasis> gene induces formation of multinucleate cells through overduplication of the centrosome |
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| Authors: | Eishi?Funakoshi Takamitsu?Hori Tokuko?Haraguchi Yasushi?Hiraoka Jun?Kudoh Nobuyoshi?Shimizu |
| Institution: | (1) Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka 573-0101, Japan;(2) Communications Research Laboratory, Kansai Advanced Research Center, 588-2 Iwaoka, Iwaoka-cho, Nishi-ku Kobe, 651-2492, Japan;(3) Department of Biology, Graduate School of Science, Osaka University, 1-16 Machikaneyama, Osaka 560-0043, Japan;(4) Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan |
| Abstract: | BackgroundPreviously we cloned the human MNB/DYRK1A gene from the "Down syndrome critical region" on chromosome 21. This gene encodes a dual specificity protein kinase that catalyzes its autophosphorylation on serine/threonine and tyrosine residues. But, the functions of the MNB/DYRK1A gene in cellular processes are unknown. |
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