Localization of metabotropic glutamate receptors in the outer plexiform layer of the goldfish retina |
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Authors: | Christina Joselevitch Jan Klooster Maarten Kamermans |
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Institution: | (1) Retinal Signal Processing, The Netherlands Institute for Neuroscience (KNAW), Meibergdreef 47, 1105 BA Amsterdam, The Netherlands |
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Abstract: | We studied the localization of metabotropic glutamate receptors (mGluRs) in the goldfish outer plexiform layer by light-and
electron-microscopical immunohistochemistry. The mGluR1α antibody labeled putative ON-type bipolar cell dendrites and horizontal
cell processes in both rod spherules and cone triads. Immunolabeling for mGluR2/3 was absent in the rod synaptic complex but
was found at horizontal cell dendrites directly opposing the cone synaptic ribbon. The mGluR5 antibody labeled Müller cell
processes wrapping rod terminals and horizontal cell somata. The mGluR7 antibody labeled mainly horizontal cell dendrites
invaginating rods and cones and some putative bipolar cell dendrites in the cone synaptic complex. The finding of abundant
expression of various mGluRs in bipolar and horizontal cell dendrites suggests multiple sites of glutamatergic modulation
in the outer retina.
Financial support for this work was provided by Conselho Nacional de Pesquisa (CNPq), Brazil (grant 200915/98-3 to C.J.) |
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Keywords: | Metabotropic glutamate receptor Retina Electron microscopy Immunohistochemistry Bipolar cell Horizontal cell Goldfish Carassius auratus (Teleostei) |
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