Effect of alpha-MSH on the corticosteroid production of isolated zona glomerulosa and zona fasciculata cells |
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Authors: | Katalin Sz Szalay E Stark |
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Institution: | Institute of Experimental Medicine, Hungarian Academy of Sciences 1450 Budapest, P.O.B. 67., Hungary |
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Abstract: | α-MSH (10?9 ? 6×10?7M) potentiates the effect of ACTH (10?11 ? 5×10?9M) on adrenocortical steroidogenesis decreassng ED50 of ACTH from 220 to 183 pg/ml on zona fasciculata corticosterone-, and from 739 to 437 pg/ml on zona glomerulosa aldosterone production. α-MSH alone increases aldosterone production of zona glomerulosa cells in doses (10?9 ? 6×10?7M) that do not stimulate zona fasciculata corticosterone production. The response of zona glomerulosa aldosterone production to α-MSH can be characterized by a bi-phase dose-response curve. |
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