Low-dose apomorphine reduces serum homovanillic acid concentrations in schizophrenic patients |
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| Authors: | Neal R Cutler Dilip V Jeste Farouk Karoum Richard Jed Wyatt |
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| Institution: | Adult Psychiatry Branch, Division of Special Mental Health Intramural Research Program, Saint Elizabeths Hospital Washington, D.C. 20032, USA |
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| Abstract: | This study was carried out to evaluate the postulated dopaminergic autoreceptor regulatory effect in man of low-dose apomorphine. Behavior and serum homovanillic acid concentrations following low-dose apomorphine were investigated. Five medicated chronic schizophrenic patients had serum homovanillic acid concentrations measured by mass fragmentography before and after 0.005 mg/kg of apomorphine or saline placebo. Results demonstrate significant reductions in serum homovanillic acid concentrations in all five subjects following apomorphine as compared with placebo. These findings present direct evidence of a specific dopamine autoreceptor effect of low-dose apomorphine in schizophrenic patients. |
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