Myoinositol decreases N-nitroso-N-methylurethane induced lung surfactant deficiency |
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Authors: | Mikko Hallman Benita L Epstein |
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Institution: | Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, California 92093, USA |
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Abstract: | Administration of 7.5 mg/kg body wt. of N-nitroso-N-methylurethane subcutaneously to rabbits decreased disaturated phosphatidylcholine, phosphatidylglycerol, and increased the minimum surface tension of alveolar lavage return. As compared to rabbits treated with N-nitroso-N-methylurethane alone, myoinositol supplementation (3–7 g/kg per day) of N-nitroso-N-methylurethane treated animals largely prevented both the decrease in disaturated phosphatidylcholine, and the increase in minimum surface tension. Myoinositol may be an important nutrient following damage of alveolar epithelium. |
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