Comparison of mammary tumorigenesis between litters in relation to mammary tumor virus antigenic expression in the milk of C3H/He mice |
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Authors: | Hiroshi Nagasawa Yuko Nakajima Junji Morimoto Shunsuke Imai Yoshihiko Tsubura |
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Institution: | 1. Experimental Animal Research Laboratory, Meiji University, Tama-ku, Kawasaki, Kanagawa 214, Japan;2. Pharmacology Division, National Cancer Center Research Institute, Chuo-ku, Tokyo 104, Japan;3. The 2nd Department of Pathology, Nara Medical College, Nara 634, Japan |
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Abstract: | As a possible step to estimate the relationship between mammary tumor virus (MTV) and mammary tumorigenesis in mice, MTV antigenic expression in mother's milk and spontaneous mammary tumorigenesis in their daughters were compared between the 1st, the 2nd and the 3rd litters of the highly inbred strains of C3H/He mice with low mammary tumor incidence. While MTV antigenic expression was detected in all undiluted samples at each litter by immunodiffusion test, the amount of antigen as measured by the single radial immunodiffusion method was increased with increasing litter numbers. On the other hand, the development of preneoplastic mammary hyperplastic alveolar nodules was different little between litters and mammary tumor incidence by 13 months of age was very low with no difference in all litters. The pattern of estrous cycles and plasma prolactin level were also similar in each litter. The results suggest that spontaneous mammary tumorigenesis in mice is not always affected quantitatively by the amount of MTV when endocrine and genetical conditions are similar. |
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Keywords: | For all correspondence please address to: Prof Hiroshi Nagasawa Experimental Animal Research Laboratory Meiji University Tama-ku Kawasaki Kanagawa 214 Japan |
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