Aging and benzodiazepine binding in the rat cerebral cortex |
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| Authors: | C.C. Tsang K.V. Speeg G.R. Wilkinson |
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| Affiliation: | 1. Department of Pharmacology Vanderbilt University, USA;2. Department of Medicine Veterans Administration Medical Center Nashville, Tennessee 37232, USA |
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| Abstract: | The specific binding of 3H-diazepam in the cerebral cortex was investigated in membrane preparations from 6 and 30 month old Fischer-344 rats. No age-related differences in the association, equilibrium, or dissociation binding characteristics were observed. The increased sensitivity of the elderly to the central sedative effects of the benzodiazepines does not, therefore, appear to involve changes in binding to the receptor site located in the cortex. |
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