No evidence for a peripheral effect of L-DOPA on plasma prolactin in the rat |
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Authors: | JAM Mattheij GMJ Brouwer JG Hanstede JJM Swarts |
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Institution: | Agricultural University, Department of Animal Physiology, Haarweg 10, 6709 PJ Wageningen, The Netherlands |
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Abstract: | Male and female rats with two permanently indwelling intravenous catheters were infused for 2 hours with ovine prolactin. During equilibrium conditions the effects of intravenously injected L-DOPA and benzerazide (a blocker of dopa-decarboxylase) on steady state levels of ovine prolactin were measured. A dose of 4.5 mg L-DOPA per 100 gr body weight (b.w.) caused a transient increase of plasma ovine prolactin. A dose of 0.3 mg L-DOPA/100 gr b.w. had no effect, neither in males nor in females, while benzerazide (20 mg/100 gr b.w.) had only a slight effect. The experiments suggest that L-DOPA does not affect the peripheral uptake of prolactin from the plasma. |
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