Recent advances in chemistry,therapeutic properties and sources of polydatin |
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Authors: | Didem Şöhretoğlu Merve Yüzbaşıoğlu Baran Randolph Arroo Ayşe Kuruüzüm-Uz |
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Institution: | 1.Department of Pharmacognosy, Faculty of Pharmacy,Hacettepe University,Ankara,Turkey;2.Leicester School of Pharmacy,De Montfort University,Leicester,UK |
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Abstract: | Polydatin (PLD), the 3-O-β-glucopyranoside of the well-known stilbenoid compound resveratrol, is a major compound of Fallopia japonica (Houtt.) R. Decr. (Japanese knotweed), which is widely used in traditional Chinese medicine to treat infection, inflammatory diseases and circulatory problems. It has shown a wide range of biological activities including anti-inflammatory, anti-oxidant, anti-cancer, neuroprotective, hepatoprotective, nephroprotective and immunostimulatory effects. Although resveratrol has similar beneficial effects, its low bioavailability has remained a problem. Glycosylation increases solubility of resveratrol in an aqueous environment, thus improving its bioavailability. This has led to a growing interest in PLD. Promising results obtained from bioactivity studies have boosted an intense research on this compound. The aim of this review is to give a comprehensive overview of the botanical sources, pharmacology, biosynthesis, biotechnological production, and bioactivities of PLD, and to discuss clinical studies on this compound. |
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