effect of adenosine on adenine nucleotides and inorganic phosphate in rat blood |
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Authors: | Héctor Martínez-Valdez Vicente Madrid-Marina Enrique Piña |
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Affiliation: | Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Apartado Postal 70–159, 04510 México, D.F., Mexico |
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Abstract: | The effect of adenosine and the time response on adenine nucleotide and Pi levels in rat blood was investigated. an increase in adenine nucleotide with a concommitant decrease in Pi concentration 30, 60, and 90 minutes after the nucleoside administration were observed. Though the 100 mg/Kg dose showed the highest effect on nucleotide concentration, the maximal response on Pi content was achieved with the 50 mg/Kg dose. The results are discussed at the light of previous data obtained in hepatocytes, and using as indicators the energy charge and the phosphorylation potential. |
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