Fasciclin 2 engages EGFR in an auto-stimulatory loop to promote imaginal disc cell proliferation in Drosophila |
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Authors: | Emma Velasquez Jose A Gomez-Sanchez Emmanuelle Donier Carmen Grijota-Martinez Hugo Cabedo Luis Garcia-Alonso |
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Institution: | 1. Instituto de Neurociencias CSIC-UMH, Universidad Miguel Hernandez, Sant Joan d’Alacant, Alicante, Spain;2. Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain; The University of North Carolina at Chapel Hill, UNITED STATES |
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Abstract: | How cell to cell interactions control local tissue growth to attain a species-specific organ size is a central question in developmental biology. The Drosophila Neural Cell Adhesion Molecule, Fasciclin 2, is expressed during the development of neural and epithelial organs. Fasciclin 2 is a homophilic-interaction protein that shows moderate levels of expression in the proliferating epithelia and high levels in the differentiating non-proliferative cells of imaginal discs. Genetic interactions and mosaic analyses reveal a cell autonomous requirement of Fasciclin 2 to promote cell proliferation in imaginal discs. This function is mediated by the EGFR, and indirectly involves the JNK and Hippo signaling pathways. We further show that Fasciclin 2 physically interacts with EGFR and that, in turn, EGFR activity promotes the cell autonomous expression of Fasciclin 2 during imaginal disc growth. We propose that this auto-stimulatory loop between EGFR and Fasciclin 2 is at the core of a cell to cell interaction mechanism that controls the amount of intercalary growth in imaginal discs. |
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