ADP-ribosyl transferase,rearrangement of DNA,and cell differentiation |
| |
Authors: | Gwyn T Williams Alan P Johnstone |
| |
Institution: | 1. Department of Anatomy, University of Birmingham Medical School, Vincent Drive, B15 2TJ, Birmingham, UK 2. Department of Immunology, St. George's Hospital Medical School, Cranmer Terrace, SW17 ORE, London, UK
|
| |
Abstract: | Cell differentiation is the process by which genetic information is selectively expressed to produce cells with various morphologies and functions. The integrated changes necessary for this fundamentally important process have recently been the subject of intense study. This review will summarize data from several laboratories correlating differentiation with the activity of the enzyme ADP-ribosyl transferase and with changes in single-strand DNA breaks in various diverse eukaryotic systems. We will then discuss the implications of these observations for differentiation in general, including the possibility that rearrangement of genetic material is a widespread mechanism for controlling gene expression. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|