PDGF-D contributes to neointimal hyperplasia in rat model of vessel injury |
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Authors: | Chen Jingzhou Han Yu Lin Chunxia Zhen Yisong Song Xiaodong Teng Siyong Chen Chen Chen Yu Zhang Yinhui Hui Rutai |
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Institution: | Sino-German Laboratory for Molecular Medicine and Hypertension Division, Fuwai Hospital, Chinese Academy of Medical Sciences and National Genome Center, Beijing, PR China. |
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Abstract: | In this study, we determined the role of PDGF-D, a new member of the PDGF family, in a rat model of balloon injured artery made with a 2F catheter in Sprague-Dawley male rats. PDGF-D expression was studied in the injured and control segments of abdominal aorta. The function of PDGF-D was evaluated in rat vascular smooth muscle cells stably transfected with PDGF-D gene. We found that in normal abdominal aorta, PDGF-D was highly expressed in adventia, moderate in endothelia, and unidentified in media. Stable transfection of PDGF-D gene into vascular smooth muscle cells increased the cell migration by 2.2-fold, and the proliferation by 2.3-fold, respectively, and MMP-2 production and activity as well. These results support the fact that PDGF-D is involved in the formation of neointimal hyperplasia induced by balloon catheter injury and may serve as a target in preventing vascular restenosis after coronary angioplasty. |
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Keywords: | PDGF-D Restenosis MMP Smooth muscle cells |
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