The effects of clofibrate on acetyl-CoA carboxylase activity in hepatocytes

Summary Cytochemical localization techniques and electron microscopy were used to evaluate the effects of clofibrate on acetyl-CoA carboxylase activity. It was demonstrated that the drug inhibited the activity of acetyl-CoA carboxylase in rat hepatocytes. Although the results in one of these experiments were somewhat variable, it is suggested that the inhibition of acetyl-CoA carboxylase may be the mechanism by which clofibrate exerts its hypolipidemic effects.Research supported by USPHS Grants HE 12751, NS 05665 and 00690.Recipient of Career Research Development Award 1K3 GM 28064. The authors would like to express their appreciation to Richard L. Hogg of the Ayerst Laboratories for supplying the drug.