DNA breakage drives nuclear search |
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| Authors: | Ira Grzegorz Hastings Philip J |
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| Institution: | Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA. gira@bcm.edu |
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| Abstract: | The search for a homologous template is a fundamental, yet largely uncharacterized, reaction in DNA double-strand break repair. Two reports now demonstrate that broken chromosomes increase their movement and explore large volumes of nuclear space searching for a homologous template. Break mobility requires resection and recombination enzymes, as well as damage-checkpoint components. |
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