Corneal replication is an interferon response-independent bottleneck for virulence of herpes simplex virus 1 in the absence of virion host shutoff |
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| Authors: | Pasieka Tracy Jo Menachery Vineet D Rosato Pamela C Leib David A |
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| Institution: | Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA. |
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| Abstract: | Herpes simplex viruses lacking the virion host shutoff function (Δvhs) are avirulent and hypersensitive to type I and type II interferon (IFN). In this study, we demonstrate that even in the absence of IFN responses in AG129 (IFN-αβγR(-/-)) mice, Δvhs remains highly attenuated via corneal infection but is fully virulent via intracranial infection. The data demonstrate that the interferon-independent inherent replication defect of Δvhs has a significant impact upon peripheral replication and neuroinvasion. |
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