Separation of 1,4-benzodiazepines by micellar elektrokinetic capillary chromatography |
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Authors: | Hancu Gabriel Gáspár Attila Gyéresi Arpád |
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Institution: | University of Medicine and Pharmacy, Targu Mure?, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 540139 Targu Mure?, Romania. g_hancu@rdslink.ro |
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Abstract: | In this work the applicability of micellar elektrokinetic capillary chromatography (MECC) for the determination of benzodiazepines (BZD) has been studied. The applied method was used for the simultaneous separation of 8 BZDs (alprazolam, bromazepam, chlordiazepoxide, diazepam, flunitrazepam, medazepam, oxazepam, nitrazepam), and also for the study of stability in acidic medium. A fast and reliable method has been developed; using a separation buffer composed of sodium tetraborate 25 mM (pH 9.5), SDS (50 mM) and methanol (at least 12%) as an organic modifier. |
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Keywords: | Benzodiazepines Capillary electrophoresis Separation Stability |
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