Cellular aspects of pathogenesis of hypertrophic cardiomyopathy: Role of cardiomyocyte polyploidy and activation of nuclear antigen of the proliferating cell in myocardium |
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| Authors: | E. V. Shlyakhto L. A. Bokeria M. G. Rybakova E. N. Semernin G. V. Selivanova T. D. Vlasova K. B. Borisov V. N. Parfenov A. Ya. Goodkova |
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| Affiliation: | (1) Acad. G. F. Lang Department of Facultative Therapy, Acad. I.P. Pavlov State Medical University, St. Petersburg, Russia;(2) Acad. A.N. Bakulev Research Center of Cardiovascular Surgery, Moscow, Russia;(3) Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia |
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| Abstract: | For a comparative analysis of cytomorphological characteristics of hypertrophied interventricular septum (IVS), both patients different ages with severe courses of obstructive hypertrophic cardiomyopathy (OHCMP) were examined, including children, and patients with essential arterial hypertension (EAH). The course of OHCMP in children as compared with adults was found to be characterized by considerable IVS hypertrophy that was accompanied by an acceleration of cardiomyocyte polyploidization. The mean ploidy level of cardiomyocytes in children with OHCMP was higher than in adult patients. The mean ploidy level of nuclei, the number of prolipherative cell nuclear antigen (PCNA)-positive nuclei, and the number of polyploid cardiomyocyte nuclei in adult patients with OHCMP were significantly higher statistically than in patients with EAH. The PCNA-positive labels in stromal cells were revealed only in patients with OHCMP. The obtained data indicate an important role of cardiomyocyte polyploidy and of activation of the proliferating cell nuclear antigen in development of myocardial hypertrophy in patients with OHCMP. |
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| Keywords: | obstructive hypertrophic cardiomyopathy polyploidy cardiomyocytes stromal cells |
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