6-Substituted and 19-substituted androst-4-ene-3,17-dione derivatives as potential aromatase inhibitors [Poster 10] |
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| Authors: | Tadao Terasawa Toshihiko Okada Megumi Kanda Goro Kato Tetsuro Suzuki |
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| Institution: | Shionogi Research Laboratories, Shionogi & Co., Ltd., Fukushima-ku, Osaka 553, Japan |
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| Abstract: | Various 6-substituted and 19-substituted androst-4-ene-3, 17-dione analogs were synthesized and evaluated as aromatase inhibitors. The more effective competitive inhibitors were 6-azido, 6-thiocyanate, 6-propargyloxy, 6-(2'-azidoethyl)thio, 19-azido, 19-thiocyanato, and 19-methylxanthogenyl derivatives. |
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