Measurement of nerve growth factor-like immunoreactivity in human brain using an anti-mouse-NGF enzyme immunoassay. |
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| Authors: | P Bertrand O Roger R Houlgatte F Javoy-Agid J P Brandel A Doble J C Blanchard |
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| Affiliation: | Rh?ne-Poulenc Rorer, Centre de Recherche de Vitry-Alfortville, Vitry Sur Seine, France. |
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| Abstract: | Nerve growth factor (NGF) like immunoreactivity, expressed as mouse 2.5S nerve growth factor equivalents, was evaluated in three structures of the human brain post-mortem using a commercially available enzyme immunoassay. Regional differences in NGF-like immunoreactivity were observed. Highest levels were found in hippocampus (148 pg/g) compared to putamen (76 pg/g) and frontal cortex (34 pg/g). In addition, these results suggest differences in the distribution of brain NGF between human and rodent, where relatively high levels of NGF are found in the cortex. |
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