Systematic analysis of the effect of multiple templates on the accuracy of comparative models of protein structure |
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Authors: | Suvobrata Chakravarty Sucheta Godbole Bing Zhang Seth Berger Roberto Sanchez |
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Institution: | (1) Department of Structural and Chemical Biology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA |
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Abstract: | Background Although multiple templates are frequently used in comparative modeling, the effect of inclusion of additional template(s)
on model accuracy (when compared to that of corresponding single-template based models) is not clear. To address this, we
systematically analyze two-template models, the simplest case of multiple-template modeling. For an existing target-template
pair (single-template modeling), a two-template based model of the target sequence is constructed by including an additional
template without changing the original alignment to measure the effect of the second template on model accuracy. |
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Keywords: | |
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