Characterization of a novel ADPase in Bothrops jararaca snake venom involved in nucleotide hydrolysis |
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| Authors: | Teixeira-Ferreira André Alves Elias Walter |
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| Affiliation: | Laboratório de Química e Fun??o de Proteínas e Peptídeos, Universidade Estadual do Norte Fluminense, Avenida Alberto Lamego 2000, Campos dos Goytacazes, RJ, Brazil. |
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| Abstract: | Snake venoms hydrolyze several phosphorylated substrates. However, not is clearly understood which enzyme(s) is (are) involved in these process. Here, we propose the existence of an independent ADPase activity. In addition, we studied the reactions mechanism of nucleotide hydrolysis. This system resembles membrane ecto-nucleotidases and acts with a multi enzymatic complex transforming ATP in adenosine without the accumulation of intermediates. |
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